Investigation: "Down Syndrome: An Insight of the Disease"

The article "Down Syndrome: An Insight of the Disease" published in the Journal of Biomedical Science provides an overview of Down syndrome (DS), a genetic disorder affecting approximately one in every 700 live births. The article describes the genetic basis of the condition, its clinical features, and associated medical conditions. Down Syndrome is caused by an extra copy of chromosome 21, which leads to overexpression of genes on this chromosome that results in a range of developmental and medical problems. These include intellectual disability, heart defects, and an increased risk of developing Alzheimer's disease later in life. The article discusses the physical characteristics of Down syndrome, such as being shorter in height, a flat facial profile, and an upward slant to the eyes. Individuals with DS also have an increased risk of developing certain medical conditions, such as respiratory infections and leukemia. The article emphasizes the importance of early diagnosis and intervention in managing the medical and developmental issues associated with DS. Additionally, it highlights the need for continued research into the underlying genetic mechanisms of the disorder to better understand its pathophysiology and develop more effective treatments. This article provides a comprehensive overview of DS, including its genetic basis, clinical features, and associated medical conditions. It underscores the importance of early diagnosis and intervention and emphasizes the need for ongoing research to better understand and manage this complex disorder.

This article provides an overview of Down syndrome, including its genetic basis, clinical features, and associated medical conditions. The article emphasizes the importance of a timely diagnosis and intervention in addressing the medical and developmental issues associated with Down syndrome and highlights the need for continued research into the underlying genetic mechanisms of the disorder to better understand its pathophysiology and develop more effective treatments.

The article, "Down Syndrome: An Insight of the Disease" is from a peer-reviewed journal, the Journal of Biomedical Science. The authors of the article are Asim, A., Kumar, A., Muthuswamy, S., et al., and they are from various institutions in India. The article was published on March 27, 2015, and it provides an unbiased overview of Down syndrome, its genetic basis, clinical features, and associated medical conditions. The article does not show any signs of bias or sponsorship, and it does not appear to be an advertisement.

Reference

Asim, A., Kumar, A., Muthuswamy, S. et al. “Down syndrome: an insight of the disease”. J Biomed Sci 22, 41 (2015). https://doi.org/10.1186/s12929-015-0138-y